BioMAP^® Technology: A Systems Biology Approach

Systems biology has quickly become a well-established approach to biological study that aims to describe and understand the operation of complex biological systems as a whole, taking into account the intricate interactions of gene, protein and cell elements. Ultimately its goal is to develop predictive models of human disease. Systems biology approaches offer the potential to improve decision making in pharmaceutical drug development by accelerating hypothesis-driven biology, the selection and validation of drug targets and lead compounds, and identification of surrogate markers for clinical studies. Our BioMAP^® technology represents an innovative systems biology approach, since it uses complex human cell systems themselves to interpret and predict the biological activities of drugs and gene targets. By integrating a broad range of disease-relevant human biology early into the drug discovery process, BioMAP^® Systems help to inform target selection and compound validation, lead optimization, and clinical indication selection.