BioMAP Systems Publications

Biological complexity and drug discovery: a practical systems biology approach.
Berg EL, Kunkel EJ, Hytopoulos E.  
IEE Proc.-Syst. Biol., Vol. 152, No. 4, December 2005

Can cell systems biology rescue drug discovery?
Butcher, EC.
Nat Rev Drug Discov. 2005 Jun;4(6):461-7.

Approaches to the analysis of cell signaling networks and their application in drug discovery.
Berg EL, Hytopoulos E, Plavec I, Kunkel EJ.
Curr Opin Drug Discov Devel. 2005 Jan;8(1):107-14.

Systems biology in drug discovery.[pdf]
Butcher EC, Berg EL, Kunkel EJ.
Nature Biotechnol. 2004 Oct;22(10):1253-9.

Rapid structure-activity and selectivity analysis of kinase inhibitors by BioMAP analysis in complex human primary cell-based models.
Kunkel EJ, Plavec I, Nguyen D, Melrose J, Rosler ES, Kao LT, Wang Y, Hytopoulos E, Bishop AC, Bateman R, Shokat KM, Butcher EC, Berg EL.
Assay Drug Dev Technol. 2004 Aug;2(4):431-41.

An integrative biology approach for analysis of drug action in models of human vascular inflammation.
Kunkel EJ, Dea M, Ebens A, Hytopoulos E, Melrose J, Nguyen D, Ota KS, Plavec I, Wang Y, Watson SR, Butcher EC, Berg EL.
FASEB J. 2004 Aug;18(11):1279-81. Epub 2004 Jun 18.

Method for analyzing signaling networks in complex cellular systems.
Plavec I, Sirenko O, Privat S, Wang Y, Dajee M, Melrose J, Nakao B, Hytopoulos E, Berg EL, Butcher EC.
Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1223-8. Epub 2004 Jan 26.