Systems Biology
The goal of modern systems biology is to describe and understand the operation of complex biological systems and ultimately to develop predictive models of human disease. “Systems biology” encompasses many different approaches, including the generation and analysis of large scale gene, protein and metabolite datasets; computer modeling of disease or organ system physiology; and the use of complex human cell systems themselves (e.g BioMAP technology) to interpret and predict the biological activities of drugs and gene targets.
Systems biology and drug discovery
”Systems biology” approaches offer the potential to improve decision making in pharmaceutical drug development by accelerating hypothesis-driven biology, the selection and validation of drug targets and lead compounds, and identification of surrogate markers for clinical studies. Complex cell systems technologies, such as BioMAP, integrate a broad range of disease-relevant human biology into the drug discovery process, informing target and compound validation, lead optimization, and clinical indication selection. For further reading, see Butcher EC, Berg EL, Kunkel EJ. Systems Biology in Drug Discovery (below).
Books & Articles
Aderem, A. “Systems biology: its practice and challenges.” Cell.
2005 May 20;121(4):511-3. PMID: 15907465
Butcher EC, Berg EL, Kunkel EJ. Systems biology in drug discovery. [pdf]
Nat Biotechnol. 2004 Oct;22(10):1253-9. PMID: 15470465
Christopher R, Dhiman A, Fox J, Gendelman R, Haberitcher T,
Kagle D, Spizz G, Khalil IG, Hill C. Data-driven computer
simulation of human cancer cell. Ann N Y Acad Sci. 2004
May;1020:132-53. PMID: 15208190
Davidson EH, Rast JP, Oliveri P, Ransick A, Calestani C, Yuh
CH, Minokawa T, Amore G, Hinman V, Arenas-Mena C, Otim O, Brown
CT, Livi CB, Lee PY, Revilla R, Rust AG, Pan Z, Schilstra MJ,
Clarke PJ, Arnone MI, Rowen L, Cameron RA, McClay DR, Hood
L, Bolouri H. A genomic regulatory network for development.
Science. 2002 Mar 1;295(5560):1669-78. PMID: 11872831
Huang S. Back to the biology in systems biology: what can
we learn from biomolecular networks? Brief Funct Genomic Proteomic.
2004 Feb;2(4):279-97. PMID 15163364
Hood L, Heath JR, Phelps ME, Lin B. Systems biology and new
technologies enable predictive and preventative medicine.
Science. 2004 Oct 22;306(5696):640-3. PMID 15499008
Ideker T, Lauffenburger D. Building with a scaffold: emerging
strategies for high- to low-level cellular modeling. Trends
Biotechnol. 2003 Jun;21(6):255-62. PMID 12788545
Janes KA, Lauffenburger DA. A biological approach to computational
models of proteomic networks. Curr Opin Chem Biol. 2006
Feb;10(1):73-80. PMID: 16406679
Kitano H. Systems biology: a brief overview. Science.
2002 Mar 1;295(5560):1662-4. PMID 11872829
Nicholson JK, Wilson ID. Opinion: understanding 'global' systems
biology: metabonomics and the continuum of metabolism. Nat
Rev Drug Discov. 2003 Aug;2(8):668-76. PMID: 12904817
Thomas CE, Ganji G. Integration of genomic and metabonomic data in systems
biology--are we 'there' yet? Curr Opin Drug Discov Devel.
2006 Jan;9(1):92-100. PMID: 16445121
Foundations of Systems Biology, Hiraoki Kitano, ed., The MIT Press
From MIT Press
From amazon.com
PDF of the first chapters
From genetic-programming.com
Walter Sneader, Drug Discovery, A History
http://www.wiley.com
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