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color: black; font-family: tahoma; font-weight:bold">Milestones</font></p> <p><font style="font-size: 9pt; color: black; font-family: tahoma;"><a name="may2008"></a></p> <table width="96%" border="0" cellspacing="0" cellpadding="10"> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2008</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">April</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek initiates research collaboration with <strong>Lexicon Pharmaceuticals, Inc.</strong> to apply its BioMAP<sup>®</sup> Systems to help evaluate selected compounds associated with several of Lexicon's drug discovery programs. </font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">Feburary</font></td> <td><font style="font-size: 9pt; font-family: tahoma;"><strong>Roy A. Whitfield</strong>, former Chairman and CEO, Incyte Corporation, and member of the BioSeek Board of Directors since 2006, elected <strong>Executive Chairman of the Board</strong>. </font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">January</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek enters into a collaboration agreement with <a href="http://www.ds-pharma.co.jp/english/" target=_blank>Dainippon Sumitomo Pharma Co.</a> (DSP) to apply its BioMAP<sup>®</sup> Systems to support compound differentiation, lead development, and drug candidate selection activities for DSP's discovery programs in the fields of inflammation and metabolic diseases.</font></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2007</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">December</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek enters into a collaboration agreement with <a href="http://www.ucb.com/" target=_blank>UCB</a> to apply its BioMAP<sup>®</sup> Systems to evaluate a number of UCB compounds across several target classes, in support of target differentiation, lead development, and drug candidate selection activities.</font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">November</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">Michael C. Venuti, PhD, joins BioSeek as its Chief Executive Officer and member of the Board of Directors. </font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">May</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek enters into joint research collaboration with Amylin Pharmaceuticals to discover novel peptide therapeutics. </font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">May</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">Amylin Pharmaceuticals makes $10 million equity investment in BioSeek.</font></a></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">April</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">U.S. Environmental Protection Agency (EPA) awards BioSeek a contract to use BioMAP<sup>®</sup> Systems technology to profile the toxic effects of compounds in the agency's <a href="http://www.epa.gov/comptox/toxcast/" target=_blank>ToxCast<sup>"!</sup></a> program. </font></a></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2006</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">August</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek enters agreement with <strong>Amylin Pharmaceuticals</strong> to apply its BioMAP<sup>®</sup> Systems technology to screen and evaluate peptides from Amylin's proprietary peptide hormone library with the objective of identifying peptides that are candidates for development as novel therapeutic agents, focusing primarily on inflammatory diseases.</font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">July</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek enters into collaboration agreement with <strong>GlaxoSmithKline</strong> (GSK). to apply its BioMAP<sup>®</sup> Systems for the characterization of compounds from GSK. </font></a></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2005</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">August</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek closes an additional financing round of $4.15MM, and recapitalizes the company. </font></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2004</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">October</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">The <strong>Royal Swedish Academy of Sciences</strong> awards Eugene C. Butcher PhD, BioSeek co-founder and pathology professor at Stanford University its 2004 Crafoord Prize in Polyarthritis. </font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">July</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek completes its Series B round of venture funding for $5.6 million, with all of its Series A venture investors participating. </font></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2003</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">December</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek awarded key patent from <strong>United States Patent and Trademark Office</strong> (No. 6,656,695), entitled "BioMAP<sup>®</sup> Characterization of Biologically Active Agents" covering key methods and applications of BioMAP technology for screening compounds as potential therapeutics for inflammatory diseases.</font></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">June</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek awarded a two-year Small Business Innovation Research (SBIR) Phase II grant from the <strong>National Institutes of Health (NIH)</strong> to support the expansion of BioSeek's Biological Multiplexed Activity Profiling (BioMAP) technology for compound validation and prioritization in human primary cell-based inflammatory disease models.</font></td> </tr> <tr valign="top"> <td width="21%"><font style="font-size: 9pt; color: black; font-family: tahoma;"><strong>2002</strong></td> <td width="79%" valign="bottom"><hr size="1" noshade></td> </tr> <tr valign="top"> <td class="body"><p><font style="font-size: 9pt; color: black; font-family: tahoma;">February</font></td> <td><font style="font-size: 9pt; font-family: tahoma;">BioSeek Completes <strong>$8.4 Million Series A Financing</strong>. The Series A round investors are Bay City Capital, Fremont Ventures, SImile Investors LLC and Vanguard V. </font></td> </tr> </table> </table></td> <td width="10" align="right"></td> </tr> </table></td> </tr> </table> </div> <!-------------------------------------GOOGLE TRACKING------------------------------> <script type="text/javascript"> var gaJsHost = (("https:" == document.location.protocol) ? "https://ssl." : "http://www."); document.write(unescape("%3Cscript src='" + gaJsHost + "google-analytics.com/ga.js' type='text/javascript'%3E%3C/script%3E")); </script> <script type="text/javascript"> try { var pageTracker = _gat._getTracker("UA-483128-3"); pageTracker._trackPageview(); } catch(err) {}</script> <!-----------------------------------------------------------------------------------> <map name="Map"> <area shape="rect" coords="4,1,98,33" href="index.htm"> </map> </body> </html>